In a minority of cases, disorders such as fragile X syndrome, tuberous sclerosis, untreated phenylketonuria (PKU), and congenital rubella cause autistic behavior. Other disorders, including Tourette syndrome, learning disabilities, and attention deficit disorder, often occur with autism but do not cause it. While people with schizophrenia may show some autistic-like behavior, their symptoms usually do not appear until the late teens or early adulthood. Most people with schizophrenia also have hallucinations and delusions, which are not found in autism.
What role does genetics play?
Recent studies strongly suggest that some people have a genetic predisposition
to autism. Scientists estimate that, in families with one autistic child,
the risk of having a second child with the disorder is approximately five
percent, or one in 20, which is greater than the risk for the general population
(see "What is autism?"). Researchers are looking for clues about
which genes contribute to this increased susceptibility. In some cases, parents
and other relatives of an autistic person show mild social, communicative,
or repetitive behaviors that allow them to function normally but appear linked
to autism. Evidence also suggests that some affective, or emotional, disorders
occur more frequently than average in families of people with autism.
Do symptoms of autism change over time?
Symptoms in many children with autism improve with intervention or as the children
mature. Some people with autism eventually lead normal or near-normal lives.
About a third of children with autistic spectrum disorders eventually develop
epilepsy. The risk is highest in children with severe cognitive impairment and
motor deficits. Adolescence may worsen behavior problems in some children with
autism, who may become depressed or increasingly unmanageable. Parents should
be ready to adjust treatment for their child's changing needs. Next
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